ABSTRACT
Background: Novel coronavirus disease caused by SARSCoV- 2, primarily manifest as an acute respiratory illness;however, it can also affect multiple organs, such as kidneys, heart, digestive tract, hematological and the nervous system. Acute kidney injury (AKI) has been reported in up to 25% of critically-ill patients with SARS-CoV-2 infection, especially in those with underlying comorbidities. Aim of the Study: To study the incidence of Acute Kidney Injury in hospitalized COVID-19 patients. Methods: This is a retrospective study conducted in Dept of Respiratory Medicine, KIMS Hospital and Research Centre, Bengaluru. A total of 1000 COVID patients were taken in the order of their admission to the hospital from Jan -May 2021. Blood urea and serum creatinine levels at the time of admission was collected. Ethical clearance was obtained from the institutional ethical committee. Results: Statistically significant correlation was found between the incidence of AKI and the COVID-19 disease severity and mortality. Correlation by Pearson 2 tailed shows a positive correlation with a value of 0.713. Patients with renal involvement had higher overall mortality compared with patients without renal involvement. Adverse short-term outcomes of renal involvement were associated with severity of COVID-19 pneumonia Conclusion: AKI could be used as a clinical characteristic in severity classification and risk stratification. Further investigation of the underlying mechanism of renal disease in COVID-19 would be needed to clarify possible therapeutic targets.
ABSTRACT
Background: COVID-19 caused by SARS-CoV-2 has led to an ongoing pandemic with massive global health and socioeconomic consequences. Monocytes are recruited under pathological conditions like viral infections to the affected tissue to defend the organism against invading pathogens and to aid in efficient resolution of inflammation. Some studies had suggested a significant decrease of monocytes in COVID-19 patients with severe or critical disease whereas some others suggested monocytosis. Aim of the Study: To find the association of Monocyte count alterations with the severity of COVID-19. Methods: This is a retrospective study conducted in Dept of Respiratory Medicine, KIMS Hospital and Research Centre, Bengaluru. A total of 1000 COVID patients were taken in the order of their admission from Jan-May 2021. Monocyte count in the blood at the time of admission was collected. Ethical clearance was obtained from the institutional ethical committee. Results: Higher monocyte count was seen in the younger age group, particularly in Category B COVID-19 patients. Statistically significant association was found between low monocyte count and the disease severity and mortality in patients with COVID-19. Conclusion: It is inferred that monocytes proliferate to eliminate the viruses in mild patients, while the loss of monocytes in the critical patients suggest that innate immunity might be suppressed to a certain extent in critical COVID-19. Deviation in monocytes count from the normal is a valuable discriminator for diagnosis of COVID-19 and suitable anticipator of overall spectrum of adverse consequences.